Open Positions

About the job

We are looking for an exceptional chemist to help develop the next generation of delivery chemistries for nucleic acid medicines.

You would join a growing team of 25 in-house PhD scientists and engineers spanning virology, immunology, synthetic biology, chemical formulation, in vivo biology, and robotics.

About You

You have a PhD in Chemistry, Materials Science (or a related field) and expertise in at least ONE of the following fields:

• Conjugate and Delivery Chemistry: Design and synthesis of delivery-enabling conjugates, including polymer, peptide, lipid, carbohydrate, or small-molecule based strategies (e.g., GalNAc).

• Medicinal Chemistry: Optimization of linkers (cleavable/stable) to tune stability, biodistribution, PK, or potency.

• Nucleic Acid Synthesis: Solid-phase synthesis of RNA/DNA (siRNA, ASO) including backbone, sugar, and base modifications.

• Formulation: Experience with solid-state formulation or particle engineering approaches, including spray drying, lyophilization, or dry-powder inhalation (DPI).

• Analytical Chemistry: Proficiency with LC-MS, HPLC, and purity/identity assessments

Education: PhD (Required) 

Experience: 4+ years of R&D experience

Location: Rockville, MD (On-Site)

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About You

We are looking for an exceptional and hands-on in vivo biologist to help us develop and test first-in-class nucleic acid medicines from influenza to colon cancer.

You would join a growing team of 25 in-house PhD scientists and engineers spanning virology, immunology, synthetic biology, chemical formulation, in vivo biology, and robotics.

About the Role

This role requires deep experimental ownership: you will design and execute critical experiments, generate and interpret data, and experimentally drive first-in-class preclinical programs to the clinic.

You should have a Ph.D. and 4+ years of experience ONE or more of:

• In vivo safety/efficacy testing: Developing and testing therapeutic or vaccine candidates in mice for: viruses, cancers, or autoimmune indicatuions.

• In vivo model development: Developing viral infection or tumor models in mice, especially for lung or liver indications (e.g. establishing respiratory infection models or orthotopic tumor models).

• Immunology: Expertise isolating and analyzing key cell populations (e.g. from blood, lungs, liver, and spleen) via flow cytometry, RT-qPCR, or in vivo imaging (BLI / IVIS).

Education: PhD (Required) 

Experience: 4+ years of in vivo research experience

Location: Rockville, MD (On-Site)

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About You

We are looking for an exceptional and hands-on virologist or cancer biologist to help us develop and test first-in-class nucleic acid medicines from influenza to colon cancer.

You would join a growing team of 25 in-house PhD scientists and engineers spanning virology, immunology, cancer biology, chemical formulation, in vivo biology, and robotics.

About the Role

You're a creative virologist, cancer biologist, or immunologist who wants to help develop next-generation therapeutics from viral pathogens to metastatic cancers.

This role requires deep experimental ownership: you will design and execute critical experiments, generate and interpret data, and experimentally drive first-in-class preclinical programs to the clinic.

You should have a Ph.D. and 4+ years of expertise in ONE or more of the following:

• Virology: Expertise developing and quantitatively testing novel antivirals in vitro or in vivo .

• Cancer Biology: Expertise probing novel cancer medicines or diagnostic modalities, including: monoclonal antibodies, immunotherapies, or cell therapies.

• Nucleic Acid Medicines: Expertise developing and chemically optimizing RNA or DNA medicines (e.g. mRNA, siRNA, ASO, aptamers).

• Cell-Based Screening: Design and validation of cell-based (e.g. high-throughput) assays to identify and screen novel therapeutic candidates.

Education: PhD (Required) 

Experience: 4+ years of laboratory research experience

Location: Rockville, MD (On-Site)

Apply