Open Positions

The Role

We are looking for an exceptional and creative synthetic chemist to develop next-generation delivery chemistries for oligonucleotide medicines.

This role focuses on ligand conjugation, linker design, polymer chemistry, and related strategies to enable precision extrahepatic delivery.

You will join a growing team of 25 in-house PhD scientists and engineers.

About You

You have a PhD in Chemistry, Materials Science or a related field and expertisein ONE or more of:

• Bioconjugation & Delivery Chemistries:

  Design and synthesis of delivery-enabling oligonucleotide conjugates— including polymer, peptide, lipid, or carbohydrate ligands. While our goal is extrahepatic delivery, expertise with established hepatic platforms (e.g., GalNAc) is highly valued as a transferable skill.

• Solid-Phase Synthesis:

  Chemical synthesis, deprotection, purification, and characterization of RNA or DNA (e.g., siRNA, ASOs), including backbone, sugar, and base modifications. Experience with purification methods such as HPLC, ion-exchange, reversed-phase, size-exclusion chromatography, or PAGE is preferred.

• Medicinal Chemistry of Oligonucleotides:

  SAR-based optimization of linker and ligand chemistries to tune stability, biodistribution, pharmacokinetics (PK), and potency.

• Nice to Have (not required):

  • Proficiency with LC-MS or related analytical methods to assess purity, identity, product quality, or PK / biodistribution of oligonucleotides.

  • Experience with formulation or particle engineering approaches relevant to nucleic acid therapeutics, including spray drying, lyophilization, or dry-powder inhalation (DPI).

  • Experience testing candidates for safety and efficacy in vitro or in vivo 

  • Experience with CDMOs to support scale-up, cGMP manufacturing, or IND-enabling studies.

Education: PhD (Required) 

Experience: 5+ years of relevant R&D experience (PhD included)

Location: Rockville, MD (onsite)

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The Role

We are looking for an exceptional and rigorous analytical chemist to develop novel methods to characterize the identity, purity, and in vivo biodistribution of oligonucleotide therapeutic candidates.

This role spans both analytical and bioanalytical method development, with a focus on LC-MS and HPLC approaches to support oligonucleotide quality assessment, pharmacokinetics (PK), and tissue biodistribution.

Experience with oligonucleotide therapeutics is strongly preferred, but exceptional candidates from adjacent analytical chemistry fields willing to rapidly learn oligonucleotide chemistry are encouraged to apply.

You will join a growing team of 25 PhD biomedical scientists, chemists, and engineers.

About You

You have a PhD in Chemistry or a related field and demonstrated expertise in ONE or more of:

• Oligonucleotide Analytical Chemistry:
  Analytical methods for RNA or DNA oligonucleotides (e.g. siRNA, ASOs), including assessments of identity, purity, degradation products, and overall product quality.

• Chromatographic Methods:
  HPLC and related chromatographic methods relevant to oligonucleotide products, including ion-exchange, reversed-phase, SEC, or related approaches for identity, purity, and stability assessment.

• Bioanalysis for PK and Biodistribution:
  LC-MS-based quantitative workflows to enable quantification of oligonucleotides and oligonucleotide conjugates in biological matrices such as plasma, BALF, liver, lung, or other tissues for in vivo PK and biodistribution studies.

Education: PhD (Required) 

Experience: 5+ years of relevant R&D experience (including PhD)

Location: Rockville, MD (onsite)

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The Role

We are looking for an exceptional and highly responsible Senior Veterinary Technician / Senior Research Associate to support the day-to-day operations and management of our animal facility.

This role requires substantial hands-on in vivo experience and demonstrated responsibility.

You will join a growing team of 25 in-house PhD scientists and engineers.

About You

You should have 4+ years of in vivo research or veterinary technician experience in:

• Vivarium operations and animal care: Supporting day-to-day animal facility activities, including cage changes, animal weighing, health monitoring, husbandry support, and facility organization.

• In vivo study support: Assisting with mouse studies, including animal handling, dosing via multiple routes, monitoring, sample collection, necropsy support, and rigorous study documentation.

• Animal research compliance: Supporting IACUC protocols, maintaining accurate animal and study records, and helping ensure animal work is compliant with regulatory requirements.

Additional experience in ONE or more of the following is strongly preferred:

• In vivo safety/efficacy testing: Testing therapeutic or vaccine candidates in mice for: viruses, cancers, or autoimmune indications.

• In vivo model development: Developing viral infection or tumor models in mice, especially for lung or liver indications (e.g. establishing respiratory infection models or orthotopic tumor models).

• Immunology: Expertise isolating and analyzing key cell populations (e.g. from blood, lungs, liver, and spleen) via flow cytometry, RT-qPCR, or in vivo imaging (BLI / IVIS).

• Complex mouse study operations: Experience working with SCID or other immunodeficient mice or managing large mouse cohorts.

Education & Training: Bachelor’s degree or equivalent experience is required.

• AALAS certification (e.g. LATG / RLATG) or equivalent laboratory animal training is preferred.

Experience: 4+ years of hands-on in vivo research or veterinary technician experience

Location: Rockville, MD (onsite)

More Info & Apply